Volume 3 Issue 2
封面解读
Xiaodong Luan
In rodents, the heart possesses the remarkable ability for regeneration within the post-birth. Lactylation is related to the occurrence of heart disease such as heart failure. We determined an integrated study combining global proteomics, lactylome, and genome-wide RNA sequencing to elucidate the role of lactylation throughout postnatal heart development. Proteins in the mouse heart undergo substantial changes in the very early stages after birth and stabilize at 6 weeks and beyond. Lysine lactylation (Kla) plays a role in cardiac development and undergoes dynamic changes throughout the development cycle of the mouse heart, with distinct patterns during early postnatal stages for histones and non-histones. ChIP-seq data indicated that H4K12la plays a role in regulating downstream gene expression in the mouse heart, thereby influencing DNA replication and subsequently affecting the corresponding mouse phenotype. Our results suggest that histone Kla is expected to be a potential target for clinical induction of cardiac regeneration.
导读
All Papers
1.Forging paths together: The history of U.S.-China Track II Health Dialogue and the future of Chinese-American health communication
通讯作者：高福, Stephen Orlins, 刘国恩,Mark McClellan, 闫群
As two of the largest economies and countries in the world, the People's Republic of China (China) and the United States of America (U.S.) both have enormous resources and innovative talents in a number of sectors. Cooperation between both sides will be hugely beneficial to the world population, and this is especially the case with healthcare. The U.S.-China Track II Dialogue on Healthcare was set up as a forum to discuss and engage ideas on this very topic. In this dialogue, Dr. Qun Yan, head of thehLifeEditorial Office engages in a dialogue with Professor Mark McClellan, the Director of the Duke-Margolis Institute for Health Policy at Duke University and U.S. Co-Chair of the Track II Dialogue on Healthcare, Professor Gordon G Liu, Professor at Peking University and the Dean of the PKU Institute for Global Health and Development and Co-Organizer of the Track II Dialogue, Mr. Stephen Orlins, President of the National Committee on U.S.-China Relations and a Co-Organizer of the Track II Dialogue, and Professor George Fu Gao, Academician at the Chinese Academy of Sciences and former Director of the Chinese Center for Disease Control and Prevention. They discuss how and why the Track II Dialogue was created, the successes and developments of the dialogues, and what the future of American-Chinese health collaboration looks like.
引用：
Yan Q, McClellan M, Liu GG, et al. Forging paths together: The history of U.S.-China Track II Health Dialogue and the future ofChinese-American health communication.hLife2025; 3: 57–60.
2.Rethinking BCG vaccine delivery for enhanced efficacy: Are two distinct routes of BCG administration better than one?
通讯作者：Melissa Dalcina Chengalroyen
In summary, this article highlights the potential of enhancing BCG vaccine efficacy against tuberculosis through alternative administration routes. While intradermal BCG vaccination has long been the standard, its variable effectiveness against adult pulmonary TB suggests the need for new strategies. Recent studies indicate that oral BCG vaccination can significantly boost mucosal immunity, which is critical for protection against respiratory infections. Combining oral and intradermal routes may thus offer a dual advantage, eliciting both systemic and mucosal immune responses. Future research should focus on validating the safety and efficacy of this combined approach in clinical settings to improve TB prevention.
引用：
Moseki RM, Chengalroyen MD. Rethinking BCG vaccine delivery for enhanced efficacy: Are two distinct routes of BCG administration better than one?hLife2025; 3: 61–63.
3. Mechanism of microglia-mediated neuroinflammation, associated cognitive dysfunction, and therapeutic updates in Alzheimer's disease
通讯作者：Ashif Iqubal, Mohammad Kashif Iqubal
Microglial activation has a significant impact on the pathogenesis of Alzheimer’sdisease(AD).
Understanding the molecular mechanism of microglial activation is important to design, develop, or repurpose the drugs.
Various natural products or small molecules have shown a significant positive impact on microglial-activated AD.
Various clinical trials are under different phases, and in the coming time, drugs might change the landscape of AD treatment.
引用：
Ghimire A, Rehman SA, Subhani A, et al. Mechanism of microglia mediated neuroinflammation, associated cognitive dysfunction, and therapeutic updates in Alzheimer’s disease.hLife2025; 3: 64–81.
4. Epigenetic regulation of cardiac tissue development by lysine lactylation
hLife | 北京协和张抒扬、栾晓东团队利用多组学分析揭示乳酸化修饰对心脏组织发育的调控机制
通讯作者：张抒扬, 黄河, 栾晓东
本研究对Kla在心脏发育中功能作用的集中探究，突出了Kla在心脏再生和衰老中的潜在意义。通过多组学和测序分析，证明了H4K12la在调控下游基因中的关键作用。因此，组蛋白Kla作为心脏发育过程中心肌细胞周期的调节因子，有望成为临床诱导心脏再生的潜在靶点。
引用：
Luan X, Du R, Su G, et al. Epigenetic regulation of cardiac tissue development by lysine lactylation.hLife2025; 3: 82–97.
5.Lrrk2promotes M1 macrophage polarizationviaregulating cytokine (IFN-γ) and TLR4 (LPS)-mediated responses
hLife | Lrrk2基因在巨噬细胞M1极化与免疫应答中的关键作用
通讯作者：张福萍, 宋健,高平
该研究发现，LRRK2依赖于其激酶活性促进STAT1磷酸化，从而促进巨噬细胞的M1极化以及下游效应分子的表达，对巨噬细胞的免疫功能具有显著作用。这些发现不仅有助于更好地理解Lrrk2在帕金森病发病机制中的作用,也为未来针对免疫系统的治疗策略提供了新的思路——Lrrk2可能成为治疗自身免疫性疾病的潜在靶点。未来，通过进一步研究LRRK2的激酶功能及其在免疫系统中的角色，有望为帕金森病的精准治疗带来新的突破。
引用：
Kang Y, Gao P, Chen X, et al.Lrrk2 promotes M1 macrophage polarizationviaregulating cytokine (IFN-γ) and TLR4 (LPS)-mediated responses.hLife2025; 3: 98–111.
