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Editorial
Genome editing technology and medical applications
Liren Wang, Bin Zhou, Dali Li
SCIENCE CHINA Life Sciences 67(12), 2024, 2537-2539
Review
AAV-mediated gene therapies by miniature gene editing tools
Xiangfeng Kong, Tong Li, Hui Yang
SCIENCE CHINA Life Sciences 67(12), 2024, 2540-2553
CRISPR-based genetic screens advance cancer immunology
Yuanfang Cao, Xueting Li, Yumu Pan, Huahe Wang, Siyu Yang, Lingjuan Hong, Lupeng Ye
SCIENCE CHINA Life Sciences 67(12), 2024, 2554-2562
CRISPR beyond: harnessing compact RNA-guided endonucleases for enhanced genome editing
Feizuo Wang, Shengsheng Ma, Senfeng Zhang, Quanquan Ji, Chunyi Hu
SCIENCE CHINA Life Sciences 67(12), 2024, 2563-2574
Research Paper
Lipid nanoparticle-mediated base-editing of theHaolgene achieves sustainable primary hyperoxaluria type 1 therapy in rats
Dexin Zhang, Rui Zheng, Zhoutong Chen, Liren Wang, Xi Chen, Lei Yang, Yanan Huo, Shuming Yin, Dan Zhang, Jiaxin Huang, Xingang Cui, Dali Li, Hongquan Geng
SCIENCE CHINA Life Sciences 67(12), 2024, 2575-2586
Letter to the editor
rAAV-CRISPR/Cas9-mediatedin vivodelivery of porcine embryos to construct knockout pigs
Mengyu Gao, YuTing He, XingLong Zhu, WanLiu Peng, Xinmei Liu, Yanyan Zhou, Yang Deng, Qin Liu, Guangneng Liao, Yi Li, Wei Ni, Guang Yang, Jiayin Yang, Yang Yang, Lang Bai, Hong Bu, Ji Bao
SCIENCE CHINA Life Sciences 67(12), 2024, 2587-2589
Review
Gut microbiota and healthy longevity
Jia Luo, Shan Liang, Feng Jin
SCIENCE CHINA Life Sciences 67(12), 2024, 2590-2602
Unlocking the potential: advancements and future horizons in ROR1-targeted cancer therapies
Lin Li, Weixue Huang, Xiaomei Ren, Zhen Wang, Ke Ding, Linxiang Zhao, Jinwei Zhang
SCIENCE CHINA Life Sciences 67(12), 2024, 2603-2616
Crop antiviral defense: Past and future perspective
Zhirui Yang, Guangyao Li, Yongliang Zhang, Fangfang Li, Tao Zhou, Jian Ye, Xianbing Wang, Xiaoming Zhang, Zongtao Sun, Xiaorong Tao, Ming Wu, Jianguo Wu, Yi Li
SCIENCE CHINA Life Sciences 67(12), 2024, 2617-2634
Research Paper
Increase of PCSK9 expression in diabetes promotes VEGFR2 ubiquitination to inhibit endothelial function and skin wound healing
Jian-Jun Gao, Fang-Yuan Wu, Yu-Jia Liu, Le Li, Yi-Jun Lin, Yue-Ting Kang, Yue-Ming Peng, Yi-Fang Liu, Chen Wang, Zhen-Sheng Ma, Yang Cao, Hong-Yu Cao, Zhi-Wei Mo, Yan Li, Jing-Song Ou, Zhi-Jun Ou
SCIENCE CHINA Life Sciences 67(12), 2024, 2635-2649
Optimizing ABA-based chemically induced proximity for enhanced intracellular transcriptional activation and modification response to ABA
Zeng Zhou, Yue-Qi Wang, Xu-Nan Zheng, Xiao-Hong Zhang, Lu-Yao Ji, Jun-You Han, Ze-Cheng Zuo, Wei-Liang Mo, Li Zhang
SCIENCE CHINA Life Sciences 67(12), 2024, 2650-2663
Targeting STING oligomerization with licochalcone D ameliorates STING-driven inflammatory diseases
Yinghui Zhang, Yadan Liu, Bing Jiang, Lifan Chen, Jie Hu, Buying Niu, Jie Chang, Zisheng Fan, Jingyi Zhou, Yajie Wang, Dan Teng, Ning Ma, Xiaofeng Wang, Ruirui Yang, Mingyue Zheng, Sulin Zhang
SCIENCE CHINA Life Sciences 67(12), 2024, 2664-2677
Inhibition of the RXRA-PPARα-FABP4 signaling pathway alleviates vascular cellular aging by an SGLT2 inhibitor in an atherosclerotic mice model
Weiwei Zhang, Linghuan Wang, Yujia Wang, Yan Fang, Ruihua Cao, Zhiyi Fang, Dong Han, Xu Huang, Zhenghui Gu, Yingjie Zhang, Yan Zhu, Yan Ma, Feng Cao
SCIENCE CHINA Life Sciences 67(12), 2024, 2678-2691
Individual and joint exposures to PM2.5 constituents and mortality risk among the oldest-old in China
Yaqi Wang, Yang Yuan, Shaocai Mo, Fang Wang, Jing Wei, Yao Yao, Yi Zeng, Yunquan Zhang
SCIENCE CHINA Life Sciences 67(12), 2024, 2692-2700
Novel DNA methylation markers for early detection of gastric cardia adenocarcinoma and esophageal squamous cell carcinoma
Zhiyuan Fan, Jiajie Hao, Feifan He, Hao Jiang, Jinwu Wang, Minjuan Li, Xinqing Li, Ru Chen, Wenqiang Wei
SCIENCE CHINA Life Sciences 67(12), 2024, 2701-2712
Bactericidal ability of target acidic phospholipids and phagocytosis of CDC42 GTPase-mediated cytoskeletal rearrangement underlie functional conservation of CXCL12 in vertebrates
Yanqi Zhang, Ning Xia, Yazhen Hu, Wentao Zhu, Chunrong Yang, Jianguo Su
SCIENCE CHINA Life Sciences 67(12), 2024, 2713-2729
Versatile plant genome engineering using anti-CRISPR-Cas12a systems
Yao He, Shishi Liu, Long Chen, Dongkai Pu, Zhaohui Zhong, Tang Xu, Qiurong Ren, Chuan Dong, Yawei Wang, Danning Wang, Xuelian Zheng, Fengbiao Guo, Tao Zhang, Yiping Qi, Yong Zhang
SCIENCE CHINA Life Sciences 67(12), 2024, 2730-2745
Dual activation of soybean resistance againstPhytophthora sojaeby pectin lyase and degraded pectin oligosaccharides
Guangzheng Sun, Yeqiang Xia, Kuikui Li, Qinsheng Zhu, Feifei Ding, Hui Gu, Zhichao Zhang, Xinrui Li, Xuan Mi, Jun Chen, Ruoting Yao, Sicong Zhang, Haibing Ouyang, Xi Chen, Tengfei Liu, Haibin Jiang, Yao Zhao, Min Qiu, Wenwu Ye, Kaixuan Duan, Zhenchuan Ma, Suomeng Dong, Heng Yin, Yan Wang, Yuanchao Wang
SCIENCE CHINA Life Sciences 67(12), 2024, 2746-2760
Neol represents a group of transcriptional repressors regulating the biosynthesis of multiple aminoglycosides
Yue Li, Xiangxi Meng, Dong Li, Xiulei Xia, Jihui Zhang, Yihua Chen, Huarong Tan
SCIENCE CHINA Life Sciences 67(12), 2024, 2761-2770
Insight
Advances in brain tumor therapy: from molecular diagnostics to novel treatments
Junwen Zhang, Ran Mu, Fusheng Liu
SCIENCE CHINA Life Sciences 67(12), 2024, 2771-2773
New insights shed light on the enigma of genetic diversity and species complexity
Zuobin Zhu, Conghui Han, Shi Huang
SCIENCE CHINA Life Sciences 67(12), 2024, 2774-2776
Letter to the editor
Identification of malignant plasma cells in the primary mediastinal large B-cell lymphoma
Changchun Wang, Lianhui Duan, Guanyin Huang, Chang Yu, Xuping Yang, Dangchi Li, Yueyu Huang, Wenhui Shen, Xuefei Liu, Qiaoli Lv, Haiyan Yang, Weimin Mao, An Zhao
SCIENCE CHINA Life Sciences 67(12), 2024, 2777-2779
A biobank of patient derived glioma organoids
Yulin Wen, Hongmin Bai, Qing Li, Sainan Huang, Xiaokun Jia, Guangjin Pan, Hongjie Yao
SCIENCE CHINA Life Sciences 67(12), 2024, 2780-2782
Research Highlight
Rice GWAS-to-Gene uncovers the polygenic basis of traits
Xianrong Xie, Qunjie Zhang, Yao-Guang Liu
SCIENCE CHINA Life Sciences 67(12), 2024, 2783-2785
Targeted genome duplications by amplification editing (AE)
Chao Sun, Caixia Gao
SCIENCE CHINA Life Sciences 67(12), 2024, 2786-2788
