Journal of Genetics and Genomics2024年第10期(Volume 51, Issue 10, 2024)在线发表，欢迎大家下载阅读！
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https://www.sciencedirect.com/journal/journal-of-genetics-and-genomics/vol/51/issue/10
本期封面
Volume 51, Issue 10
On the cover: The phospholipase D (PLD) enzyme superfamily is pivotal in various cellular processes, notably in oncogenesis. However, its specific role in nasopharyngeal carcinoma (NPC) remains unclear. In this issue, Zhou et al. report the oncogenic role of PLD1 in NPC, demonstrating a positive feedback loop between PLD1 and the NF-κB pathway that drives NPC progression (pp. 997–1006). PLD1 enhances NF-κB activity by promoting the phosphorylation and nuclear translocation of RELA (p65). This nuclear translocation allows RELA to bind to the PLD1 promoter, enhancing its expression. The cover image illustrates this feedback loop, with two mice running on a wheel, symbolizing the mutual reinforcement between PLD1 and NF-κB. The wheel’s mechanical energy is converted into electricity, leading to an overloaded circuit board imprinted with nasopharyngeal tissue, ultimately resulting in system failure due to excessive accumulation.
本期内容简介
Volume 51, Issue 10
Review
Another piece of puzzle for the human microbiome: the gut virome under dietary modulation
Fengxiang Zhao, Jinfeng Wang
https://doi.org/10.1016/j.jgg.2024.04.013
中国农业大学王金锋教授团队发表综述论文，概述饮食干预下的肠道病毒组研究进展，包括肠道病毒组对饮食的响应与反馈，重点介绍了病毒组与细菌的互作关系，噬菌体生活方式的转变，并结合水平基因转移讨论了饮食赋予肠道病毒组和菌群的辅助代谢功能和外源性病毒引入。
Original Research
A positive feedback loop between PLD1 and NF-κB signaling promotes tumorigenesis of nasopharyngeal carcinoma
Ya-Qing Zhou, Xi-Xi Cheng, Shuai He, Shu-Qiang Liu, Yi-Qi Li, Pan-Pan Wei, Chun-Ling Luo, Jin-Xin Bei
https://doi.org/10.1016/j.jgg.2024.06.004
中山大学肿瘤防治中心贝锦新研究员团队发表研究论文，揭示PLD1调控鼻咽癌恶性进展的机制，证明其有望作为鼻咽癌潜在分子标志物及治疗靶点。(封面文章)
Deficiency of MFSD6L, an acrosome membrane protein, causes oligoasthenoteratozoospermia in humans and mice
Dapeng Zhou, Huan Wu, Lingbo Wang, Xuemei Wang, Shuyan Tang, Yiling Zhou, Jiaxiong Wang, Bangguo Wu, Jianan Tang, Xuehai Zhou, Shixiong Tian, Shuang Liu, Mingrong Lv, Xiaojin He, Li Jin, Huijuan Shi, Feng Zhang, Yunxia Cao, Chunyu Liu
https://doi.org/10.1016/j.jgg.2024.06.008
上海交通大学医学院附属国际和平妇幼保健院刘春雨副研究员、安徽医科大学曹云霞教授、复旦大学张锋教授等多中心团队合作发表研究论文，报道了少弱畸精子症新致病基因MFSD6L，该基因双等位突变通过破坏精子顶体结构导致雄性生育障碍。
Ca2+–calpains axis regulates Yki stability and activity in Drosophila
Chaojun Zhai, Yunfeng Wang, Shenao Qi, Muhan Yang, Shian Wu
https://doi.org/10.1016/j.jgg.2024.04.011
南开大学吴世安教授团队发表研究论文，揭示了果蝇中Ca2+–calpains调控Yki活性与功能的分子机制，为拓展Hippo信号通路在生理病理条件下的功能与机制研究提供了新视角。
The landscape and clinical relevance of intronic polyadenylation in human cancers
Xiaomeng Cheng, Guanghui Jiang, Xiaolan Zhou, Jing Wang, Zhaozhao Zhao, Jiayu Zhang, Ting Ni
https://doi.org/10.1016/j.jgg.2024.04.014
复旦大学生命科学学院/人类表型组研究院倪挺教授团队发表研究论文，利用TCGA数据库中33种癌症类型的RNA-seq数据，系统鉴定并发现了21,835个IPA事件，结合病人的临床数据和药物响应数据，鉴定得到临床和药物响应相关的IPA事件。研究团队进一步整合这些数据，开发了人类泛癌IPA数据库IPACancer Atlas (http://www.tingni-lab.com/Pancan_IPA/)。
miR-504 knockout regulates tumor cell proliferation and immune cell infiltration to accelerate oral cancer development
Xiaotang Wang, Xiaona Song, Yunhui Ma, Junting Yang, Jiping Gao, Tian Wang, Guoqiang Xu, Xiaoqi Chang, Shuxuan Shi, Rui Sun, Guohua Song
https://doi.org/10.1016/j.jgg.2024.06.002
山西医科大学实验动物中心宋国华教授团队发表研究论文，构建了miR-504敲除口腔癌小鼠模型，发现敲除miR-504能够加速4NQO诱导口腔癌的恶性进展，为探究口腔癌形成发展的分子机制及抗口腔癌药物研发提供合适的实验动物模型。
GPR160 regulates the self-renewal and pluripotency of mouse embryonic stem cells via JAK1/STAT3 signaling pathway
Shasha Fan, Chuanliang Guo, Guanheng Yang, Lei Hong, Hongyu Li, Ji Ma, Yiye Zhou, Shuyue Fan, Yan Xue, Fanyi Zeng
https://doi.org/10.1016/j.jgg.2024.05.003
上海交通大学医学院曾凡一研究员团队发表研究论文，揭示了GPCR家族孤儿受体GPR160通过与JAK1-LIFR-gp130复合物相互作用，调控JAK1/STAT3信号通路，参与小鼠胚胎干细胞的自我更新和多能性维持，为探究胚胎干细胞命运决定的分子机制提供新视角。
Lama1upregulation prolongs the lifespan of the dyH/dyH mouse model ofLAMA2-related congenital muscular dystrophy
Yidan Liu, Dandan Tan, Kaiyue Ma, Huaxia Luo, Jingping Mao, Jihang Luo, Qiang Shen, Luzheng Xu, Shiqi Yang, Lin Ge, Yuxuan Guo, Hong Zhang, Hui Xiong
https://doi.org/10.1016/j.jgg.2024.05.005
北京大学第一医院/北京儿童医院熊晖教授团队发表研究论文，揭示上调Lama1可以作为一种不依赖LAMA2突变的LAMA2-CMD治疗方法，早期干预可以改善疾病症状和延长寿命，为替代基因治疗在LAMA2-CMD的临床应用提供了理论基础。
S-acylation of YKT61 modulates its unconventional participation in the formation of SNARE complexes in Arabidopsis
Ting Ma, Jun-Ru Tan, Jin-Yu Lu, Sha Li, Yan Zhang
https://doi.org/10.1016/j.jgg.2024.04.007
南开大学张彦教授与山东农业大学李厦教授团队合作发表研究论文，揭示拟南芥YKT61通过棕榈酰化修饰，非常规地参与SNARE复合体形成，为植物细胞内蛋白质棕榈酰化修饰及SNARE介导的囊泡融合过程提供新思路。
Dosage effect genes modulate grain development in synthesizedTriticum durum-Haynaldia villosaallohexaploid
Zhongyu Yu, Baofeng Cui, Jin Xiao, Wu Jiao, Haiyan Wang, Zongkuan Wang, Li Sun, Qingxin Song, Jingya Yuan, Xiue Wang
https://doi.org/10.1016/j.jgg.2024.04.010
南京农业大学王秀娥教授团队发表研究论文，揭示了剂量效应基因调控合成六倍体小麦籽粒发育并影响籽粒大小的分子机制，为提高小麦产量提供了新思路。
Genome-editing of a circadian clock geneTaPRR95facilitates wheat peduncle growth and heading date
Mingxue Fu, Shaoshuai Liu, Yuqing Che, Dada Cui, Zhongyin Deng, Yang Li, Xinyu Zou, Xingchen Kong, Guoliang Chen, Min Zhang, Yifan Liu, Xiang Wang, Wei Liu, Danmei Liu, Shuaifeng Geng, Aili Li, Long Mao
https://doi.org/10.1016/j.jgg.2024.05.011
中国农业科学院作物科学研究所毛龙研究员团队发表研究论文，通过解析伪应答调节基因TaPRR95的遗传效应和作用机制，揭示了其调控小麦抽穗期和株高的功能。
Alteration of the airway microbiota is associated with the progression of post-COVID-19 chronic cough in adults: a prospective study
Peiying Huang, Zhaowei Yang, Chen Zhan, Xiaojun Xiao, Zexuan Lian, Liman Fang, Shuxin Zhong, Jiahan Xu, Mo Xian, Naijian Li, Xinru Wang, Jing Li, Ruchong Chen
https://doi.org/10.1016/j.jgg.2024.06.015
Synergy of gut microbiota and host genome in driving heterosis expression of chickens
Qiang Huang, Chaoliang Wen, Shuang Gu, Yuchen Jie, Guangqi Li, Yiyuan Yan, Chuanyao Tian, Guiqin Wu, Ning Yang
https://doi.org/10.1016/j.jgg.2024.06.011
中国农业大学动物科学技术学院杨宁教授发表研究论文，探索了肠道微生物与宿主基因对形成鸡杂种优势的协同影响，为解析杂种优势形成的分子机制提供了新见解。
Research Communications
H3K36me3 and H2A.Z coordinately modulate flowering time in Arabidopsis
Xiaoru Ji, Wenqian Liu, Fei Zhang, Yanhua Su, Yong Ding, Haitao Li
https://doi.org/10.1016/j.jgg.2024.05.012
清华大学李海涛教授团队和中国科学技术大学丁勇教授团队合作发表研究论文，揭示组蛋白甲基转移酶SDG7通过与SWR1复合物的亚基SWC6直接相互作用，促进FLC位点上组蛋白H3K36me3修饰的建立和组蛋白变体H2A.Z的沉积，从而抑制植物开花。
Jasmonate-responsive geneFtOPRinvolved in flavonoid synthesis in Tartary buckwheat
Chaonan Guan, Yaliang Shi, Yang Liu, Zelin Yi, Mengqi Ding, Liqin Hu, Yuqi He, Kaixuan Zhang, Meiliang Zhou
https://doi.org/10.1016/j.jgg.2024.04.015
中国农业科学院作物科学研究所周美亮研究员团队发表研究论文，揭示苦荞FtOPR基因通过控制JA合成提高槲皮素等黄酮类物质含量，同时增强苦荞抗病性。
Generation of theStmn2-CreERT2mouse line targeting arterial endothelial cells
Yiming Lang, Qingye Wang, Rongyu Li, Xuetao Zhou, Huisang Lin, Zhongliang Xie, Mingyue Li, Kecao Su, Jie Xu, Jun Wang, Xiao Yang, Guan Yang, Yan Teng
https://doi.org/10.1016/j.jgg.2024.05.007
军事科学院军事医学研究院/医学蛋白质组学全国重点实验室/国家蛋白质科学中心(北京)滕艳/杨冠/杨晓研究员团队发表研究论文，确定了Stmn2能够作为动脉内皮细胞的特异性标记物，建立了靶向动脉内皮细胞的可诱导Cre重组酶基因敲入小鼠模型，为进一步揭示动脉内皮细胞在血管发生和病理过程中的功能提供了有力工具。
shinySRT: shareable and interactive visualization of spatially resolved data
Zhenzhong Pan, Ran Zhou, Yuan Wang
https://doi.org/10.1016/j.jgg.2024.06.007
四川大学生物治疗全国重点实验室汪源研究员团队发表研究论文，开发了空间转录组(SRT)数据可视化分析工具shinySRT (https://github.com/silhouette99/shinySRT)，通过简化常见SRT数据格式的处理，创建交互式网页供用户探索数据，从而提高SRT数据的可访问性和可用性。
